He began his career as the singer for Persian Risk.[4] In 1986, as Persian Risk disbanded, he was recruited by Black Sabbath bassist Geezer Butler to front the Geezer Butler Band.[5][6] In 1990, he was sought out by Welsh guitarist Paul Chapman of Lone Star, UFO, and Waysted fame to front a new band, Ghost, in Orlando, Florida.[6] Sentance also assembled an American version of Persian Risk with guitarist Mark Lanoue; the band gigged in the Southern US area until their demise in 1995.
Back in the UK, he was involved in a project with members of Wraith before being asked to front the Swiss band Krokus in 1998; he appeared on their Round 13 album and stayed on for the next three years.[7] In 2005, Sentance emerged fronting Whole Lotta Metal alongside co-vocalist Tony Martin of Black Sabbath fame and other British metal session musicians, assembled for a touring cast of cover versions.[8]
Sentance also served as the voice for the Power Project who issued the Dinosaurs album in 2006. It featured Sentance and American musicians Carlos Cavazo, Jeff Pilson, and Vinny Appice.[9] On the live front, he has teamed up with Deep Purple's Don Airey & Friends and can also be heard on Airey's 2008 solo effort, A Light in the Sky, and also on Airey's 2008 album, One of a Kind, where he is the lead vocalist on all songs.[10]
Sentance issued his debut solo album, Mind Doctor, in 2008; musical guests include Airey on keyboards and the Thunder rhythm section of Harry James and Chris Childs.[11] He became the lead vocalist for Scottish rock band Nazareth in February 2015,[12] and continued to do so until December 2025.[2]