Caroline Wright

Wright joined The PHG (Population Health Genomics) Foundation in 2007, a think tank in Cambridge that looks to understand how emerging technologies (including genomics) can provide more effective healthcare and improve patient's lives.^{[citation needed]}

Wright joined the Wellcome Sanger Institute in 2011.^[4] At Sanger she managed the Deciphering Developmental Disorders project,^[5] a translational research study that makes use of exome sequencing to understand undiagnosed developmental disorders.^[6] Genome sequencing, which is now offered on the National Health Service, can improve the quality of life of children with development disorders.^[7][8] She was briefly seconded part-time to Genomics England where she was scientific lead for the 100,000 Genomes Project. In particular, Wright led on variant discovery and clinical interpretation.^[9]

Wright joined the University of Exeter in 2017, where she was made a Personal Chair in Genomic Medicine in 2020. She has worked on using genome sequencing techniques to diagnose rare diseases, and understanding penetrance in populations.^[10] She looks to understand rare disease-causing variants in genes, applied in both diagnostic and screening contexts.

In 2025, Wright was elected Fellow of the Academy of Medical Sciences.^[11][12]

• Sebastian Köhler; Sandra C Doelken; Christopher J. Mungall; et al. (January 2014). "The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data". Nucleic Acids Research. 42 (Database issue): D966-74. doi:10.1093/NAR/GKT1026. ISSN 0305-1048. PMC 3965098. PMID 24217912. Wikidata Q27927005.
• Caroline F Wright; Tomas W Fitzgerald; Wendy D Jones; et al. (17 December 2014). "Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data". The Lancet. 385 (9975): 1305–1314. doi:10.1016/S0140-6736(14)61705-0. ISSN 0140-6736. PMC 4392068. PMID 25529582. Wikidata Q30881351.
• Caroline F Wright; David R FitzPatrick; Helen V Firth (19 February 2018). "Paediatric genomics: diagnosing rare disease in children". Nature Reviews Genetics. doi:10.1038/NRG.2018.12. ISSN 1471-0056. PMID 29456250. Wikidata Q49886189.