Davis and her sister became successful in the educational field. In 1887, Davis took up a homestead in Trego County, Kansas, making a final proof on the property on March 4, 1893. During these six years, she taught in the schools and teachers' institutes of Trego, Brown, and Sheridan counties.
In 1893, Davis removed to Washington, D.C. where she attended Howard University Medical College, sessions 26, 27, 28, 29, 1893–7, and graduated M. D. in 1897. She practiced medicine in Washington until December, 1897, when she gained experience as a resident physician at Lying in Charity Hospital, Philadelphia, Pennsylvania, in 1898. After her graduation from that program in 1899, she removed to Sandusky, where she commenced her medical practice. For the next decade, she steadily progressed professionally, and also became widely recognized as a champion of women's rights, especially in the matter of obtaining the privilege of suffrage.
Davis was a leading member of the Erie County Medical Society, of which she was secretary, and was also actively identified with the Ohio State and the American Medical Associations. Her prominence as a suffragist was further indicated by the fact that for a number of years, she held the position of recording secretary of the Ohio Woman Suffrage Association. She was president of the Civic Club of Sandusky, a member of the board of managers of the Rest Room, and a member of the Daughters of the American Revolution. In religion, Davis belonged to the Congregational church.
She died in Tennessee, 22 March 1953, and willed her body to Vanderbilt University School of Medicine.[6]