Cartilage oligomeric matrix protein

COMP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FBY
Identifiers
Aliases	COMP, EDM1, EPD1, MED, PSACH, THBS5, cartilage oligomeric matrix protein, TSP5, CTS2
External IDs	OMIM: 600310; MGI: 88469; HomoloGene: 74; GeneCards: COMP; OMA:COMP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,791,305 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,834,716 bp
RNA expression pattern
	Top expressed in
	tibia; ; cartilage tissue; ; Achilles tendon; ; tendon of biceps brachii; ; synovial joint; ; popliteal artery; ; tibial arteries; ; saphenous vein; ; urethra; ; ascending aorta;
	Top expressed in
	ankle; ; tibiofemoral joint; ; fossa; ; trachea; ; intercostal muscle; ; seminiferous tubule; ; condyle; ; spermatid; ; skin of external ear; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protease binding; calcium ion binding; heparan sulfate proteoglycan binding; heparin binding; extracellular matrix structural constituent; protein binding; collagen binding; integrin binding; BMP binding; proteoglycan binding;
Cellular component	extracellular matrix; extracellular exosome; extracellular space; extracellular region; protein-containing complex; collagen-containing extracellular matrix;
Biological process	animal organ morphogenesis; growth plate cartilage development; skeletal system development; cell adhesion; extracellular matrix organization; negative regulation of apoptotic process; limb development; apoptotic process; ossification; chondrocyte development; endochondral bone growth; response to unfolded protein; blood coagulation; protein secretion; multicellular organism aging; regulation of gene expression; vascular associated smooth muscle contraction; protein processing; collagen fibril organization; bone mineralization; regulation of bone mineralization; BMP signaling pathway; multicellular organism growth; chondrocyte proliferation; tendon development; skin development; artery morphogenesis; musculoskeletal movement; neuromuscular process; cartilage development; bone morphogenesis; platelet aggregation; vascular associated smooth muscle cell development; bone growth; negative regulation of hemostasis; positive regulation of chondrocyte proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1311
	12845
	ENSG00000105664
	ENSMUSG00000031849
	P49747
	Q9R0G6
	NM_000095
	NM_016685
	NP_000086
	NP_057894
	Wikidata
View/Edit Human	View/Edit Mouse

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.^[5]^[6]^[7]