Cerdulatinib

Cerdulatinib
Clinical data
Other names	PRT062070, PRT2070, DMVT-502
Routes of; administration	By mouth
Identifiers
	IUPAC name 4-(Cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide;
CAS Number	1198300-79-6 [PubChem];
PubChem CID	44595079;
ChemSpider	32822046 ;
UNII	D1LXQ45S1O;
CompTox Dashboard (EPA)	DTXSID001115521 ;
Chemical and physical data
Formula	C20H27N7O3S
Molar mass	445.54 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N;
	InChI InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25) ; Key:BGLPECHZZQDNCD-UHFFFAOYSA-N;

Cerdulatinib is a small molecule SYK/JAK kinase inhibitor in development for treatment of hematological malignancies.^[1] It has lowest nM IC50 values against TYK2, JAK1, JAK2, JAK3, FMS, and SYK.^[2]

Other namesPRT062070, PRT2070, DMVT-502

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It is being developed by Portola Pharmaceuticals; in September 2018 the FDA granted orphan drug status to cerdulatinib for the treatment of peripheral T-cell lymphoma (PTCL).^[3]

See also

Clinical data

Other names	PRT062070, PRT2070, DMVT-502
Routes of administration	By mouth
Identifiers
IUPAC name 4-(Cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide
CAS Number	1198300-79-6^Y[PubChem]
PubChem CID	44595079
ChemSpider	32822046^Y
UNII	D1LXQ45S1O
CompTox Dashboard (EPA)	DTXSID001115521
Chemical and physical data
Formula	C₂₀H₂₇N₇O₃S
Molar mass	445.54 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
InChI InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)^Y Key:BGLPECHZZQDNCD-UHFFFAOYSA-N