Chlorcyclizine

Chlorcyclizine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682619
Routes of; administration	Oral
ATC code	R06AE04 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine;
CAS Number	82-93-9 ;
PubChem CID	2710;
ChemSpider	2609 ;
UNII	M26C4IP44P;
ChEMBL	ChEMBL22150 ;
CompTox Dashboard (EPA)	DTXSID9048011 ;
ECHA InfoCard	100.001.315
Chemical and physical data
Formula	C18H21ClN2
Molar mass	300.83 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)C;
	InChI InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3 ; Key:WFNAKBGANONZEQ-UHFFFAOYSA-N ;
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Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.^[1]^[2]^[3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.^[1]^[2]^[3] In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties.^[4]^[5] It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.^[6]^[7]^[8]