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Chlorophenylsilatrane

Chemical compound From Wikipedia, the free encyclopedia

1-(4-Chlorophenyl)silatrane is an extremely toxic[2] organosilicon compound which was developed by M&T Chemicals as a single-dose rodenticide.[1] It was never registered as rodenticide,[2] except for experimental use.[1] 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in the Project Coast.[3][4]

Quick facts Names, Identifiers ...
1-(4-Chlorophenyl)silatrane
Names
IUPAC name
1-(4-Chlorophenyl)-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane
Other names
RS-150
Caswell No. 213B
1-(p-Chlorophenyl)silatrane
5-(p-Chlorophenyl)silatrane
5-(4-Chlorophenyl)silatrane
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.252.129 Edit this at Wikidata
UNII
  • InChI=1S/C12H16ClNO3Si/c13-11-1-3-12(4-2-11)18-15-8-5-14(6-9-16-18)7-10-17-18/h1-4H,5-10H2
    Key: IKFVTMCLFHXPQF-UHFFFAOYSA-N
  • c1cc(ccc1[Si]23OCCN(CCO2)CCO3)Cl
Properties
C12H16ClNO3Si
Molar mass 285.8 g/mol
Appearance odorless, white powder[1]
Melting point 230-235 °C[1]
<0.2 g/L[1]
Solubility in Chloroform, Benzene soluble[1]
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Extremely toxic
Lethal dose or concentration (LD, LC):
1-4 mg/kg (rats, oral)[1]
3000 mg/kg (rats, dermal)[1]
0.9-2.0 mg/kg (mice, oral)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Toxicity

1-(4-Chlorophenyl)silatrane is a GABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6][7][8] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to induce poison shyness.[2] In field trials, it was less effective than zinc phosphide against wild rats.[10]

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