Chloropyridine
Index of articles associated with the same name
From Wikipedia, the free encyclopedia
Chloropyridines are a group of aryl chlorides consisting of a pyridine ring with chlorine atoms as substituents.
| Related molecular formulas | ||
|---|---|---|
| C5H6ClN | ||
| C4H2ClN | C5H4ClN | C6H6ClN |
| C5H2ClN | ||
| C5H3Cl | C5H5ClN2 | |
Chloropyridines include:
- 2-Chloropyridine
- 3-Chloropyridine
- 4-Chloropyridine
- 2,6-Dichloropyridine
Production
Direct halogenation of pyridine with chlorine gas above 270 °C gives a mixture of 2-chloropyridine and 2,6-dichloropyridine.[1]
2- and 4-chloropyridine are prepared from the corresponding pyridinols using phosphoryl chloride.[1]
Uses
Chloropyridines are important intermediates to pharmaceuticals and agrochemicals.[1] A major use of 2-chloropyridine is the production of production of the fungicide pyrithione. Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid, a step in the production of cephalosporin antibiotics.
4-Chloropyridine is a precursor to ofornine & besipirdine.
