Choline-phosphate cytidylyltransferase
Class of enzyme
From Wikipedia, the free encyclopedia
Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from guinea pig liver combines cytidine triphosphate and phosphocholine to give citicoline, with pyrophosphate (PPi) as a byproduct. It is responsible for regulating phosphatidylcholine content in membranes.[1][2][3]
In humans, the enzyme protein is encoded by the genes PCYT1A and PCYT1B.[4][5][6] These have been extensively studied.[7][8][9]
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase.[10]
