Chromosome 1 open reading frame 162
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| C1orf162 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | C1orf162, chromosome 1 open reading frame 162 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3588284; HomoloGene: 45482; GeneCards: C1orf162; OMA:C1orf162 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 1 open reading frame 162 is a protein that in humans is encoded by the C1orf162 gene. It has been found to be hypomethylated in instances of gastric cancer. [5]
mRNA
Three transcript variants have been identified. Isoform 1 is the longest transcript and encodes the longest isoform. Isoform 2 uses an alternate in-frame splice site and is shorter than isoform 1. Isoform 3 lacks an alternate in-frame exon and is shorter compared to isoform 1.[8] There are six stem loops in the 5' untranslated region and five stem loops in the 3' untranslated region.[9]
Protein
The predicted molecular weight of the protein C1orf162 is 16.9 kdal. Its isoelectric point is approximately 9.2 in mammals.[10] A single transmembrane region is conserved across species.[11] The protein is predicted to localize mainly in the nucleus.[12] The protein is predicted to be myristoylated.[13]
Expression
C1orf162 is not ubiquitously expressed in humans. According to microarray-assessed tissue expression patterns, C1orf162 is most highly expressed in bone marrow, lung, fetal liver, lymph node, spleen, and thymus in normal human tissues.[14] Staining of normal tissues has found high levels of RNA expression in bone marrow, lymph node, spleen, and lung tissue, which coincides with microarray-assessed expression patterns.[15]
Clinical Significance
One study found the protein to be one of three hypomethylated proteins in instances of gastric cancer.[16]
