Chromosome 6 open reading frame 203

AliasesMTRES1, PRED31, HSPC230, chromosome 6 open reading frame 203, mitochondrial transcription rescue factor 1, C6orf203

External IDsMGI: 1915101; HomoloGene: 41137; GeneCards: MTRES1; OMA:MTRES1 - orthologs

Chr.Chromosome 6 (human)^[1]

End107,051,586 bp^[1]

MTRES1
Identifiers
Aliases	MTRES1, PRED31, HSPC230, chromosome 6 open reading frame 203, mitochondrial transcription rescue factor 1, C6orf203
External IDs	MGI: 1915101; HomoloGene: 41137; GeneCards: MTRES1; OMA:MTRES1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 107,028,199 bp[1] End 107,051,586 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B2 Start 43,401,129 bp[2] End 43,416,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte tendon of biceps brachii secondary oocyte mucosa of transverse colon biceps brachii vastus lateralis muscle right adrenal gland right adrenal cortex muscle of thigh internal globus pallidus Top expressed in motor neuron digastric muscle sternocleidomastoid muscle facial motor nucleus temporal muscle morula triceps brachii muscle intercostal muscle vastus lateralis muscle myocardium of ventricle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51250 67851 Ensembl ENSG00000130349 ENSMUSG00000019797 UniProt Q9P0P8 Q9CQF4 RefSeq (mRNA) NM_001142468 NM_001142470 NM_016487 NM_026411 RefSeq (protein) NP_001135940 NP_001135942 NP_057571 NP_080687 Location (UCSC) Chr 6: 107.03 – 107.05 Mb Chr 10: 43.4 – 43.42 Mb PubMed search [3] [4]
Wikidata
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Chromosome 6 open reading frame 203 is a protein that in humans is encoded by the C6orf203 gene. ^[5]

C6orf203 protein is reported to be localised to the mitochondria of eukaryotes and possess an evolutionarily conserved RNA-binding domain.^[6][7]

One study propose C6orf203 to associate with mitochondrial RNA polymerase (POLRMT) and increase mitochondrial transcription to protect the cell from mitochondrial RNA loss during stress.^[7] However, another study propose C6orf203 to associate with the mitoribosomal large subunit and regulate mitochondrial translation.^[6]