Chronic eosinophilic leukemia
From Wikipedia, the free encyclopedia
| Chronic eosinophilic leukemia | |
|---|---|
| Other names | CEL |
| Specialty | Hematology, oncology |
Chronic eosinophilic leukemia is a form of cancer in which too many eosinophils are found in the bone marrow, blood, and other tissues. Most cases are associated with fusion genes. [1]
Signs and symptoms may include weight loss, fever, malaise, cough, skin and mucosal lesions, diarrhea, and peripheral neuropathy. Cardiac symptoms are also possible.[2]
In cases associated with PDGFRB and FGFR1 mutations, splenomegaly is common. Lymphadenopathy is also common with FGFR1 mutations.[2]
Infiltration of eosinophils causes organ damage.[3]
Causes
Diagnosis
For a diagnosis of CEL, hypereosinophilia with greater than 30% eosinophils is required.[4] Serum IgE is usually normal. In cases associated with PDGFRB, serum vitamin B12 and tryptase may be elevated.[2]