Based on correspondences during that time, historians have inferred that construction began on the church in 1488.[3] The architect Giuliano got his name (San Gallo) from the church.[1] In addition to the architect's last name, the gate in the Florence city wall closest to the church took on the San Gallo name: it was called Porta San Gallo. During the 1529 Siege of Florence, the Florentine army retreated within the walls of the city.[3] The church was built outside of the city walls, and because of that it was destroyed during the siege.[1]
The church displayed religious artwork. Before the church was abandoned and destroyed the art was removed and relocated inside the city's walls. The Disputation on the Trinity and the San Gallo Annunciation by Andrea del Sarto were two of the paintings taken inside the city of Florence walls.[4]
