Cicloprolol

Cicloprolol
Clinical data
Other names	Cycloprolol; SL-75177
Identifiers
	IUPAC name 1-[4-[2-(cyclopropylmethoxy)ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol;
CAS Number	63659-12-1 ;
PubChem CID	146294;
IUPHAR/BPS	552;
ChemSpider	129044;
UNII	1K2ACH4U3R;
KEGG	D03490;
ChEBI	CHEBI:135377;
ChEMBL	ChEMBL2110772;
CompTox Dashboard (EPA)	DTXSID70867026 ;
Chemical and physical data
Formula	C18H29NO4
Molar mass	323.433 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)NCC(COC1=CC=C(C=C1)OCCOCC2CC2)O;
	InChI InChI=1S/C18H29NO4/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3; Key:JNDJPKHYZWRRIS-UHFFFAOYSA-N;

Cicloprolol (INNTooltip International Nonproprietary Name; developmental code name SL-75177), or cycloprolol (BANTooltip British Approved Name), is a β-adrenergic receptor antagonist (beta blocker) described as an antihypertensive agent which was never marketed.^[1]^[2]^[3]^[4]^[5] It has weak partial agonist or intrinsic sympathomimetic activity (30%) at the β-adrenergic receptors.^[4]^[2] This is higher than that of many other beta blockers but is lower than that of xamoterol (45%).^[4] The drug is selective for the β₁-adrenergic receptor.^[3] It has been studied in the treatment of heart failure.^[3]