Cilazapril

Cilazapril
	Kekulé, stereo, skeletal formula of cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox)
Names
	Preferred IUPAC name (1S,9S)-9-{[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
Identifiers
CAS Number	88768-40-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:3698;
ChEMBL	ChEMBL515606 ;
ChemSpider	50831 ;
DrugBank	DB01340 ;
ECHA InfoCard	100.168.764
IUPHAR/BPS	6459;
KEGG	D07699 ;
PubChem CID	56330; 40467985 (1R,9S)-(2S)-butylamino isomer;
UNII	8Q9454114Q ;
CompTox Dashboard (EPA)	DTXSID1048629 ;
	InChI InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28) Key: HHHKFGXWKKUNCY-UHFFFAOYSA-N ;
	SMILES CCOC(=O)C(CCc1ccccc1)NC1CCCN2CCCC(N2C1=O)C(O)=O;
Properties
Chemical formula	C22H31N3O5
Molar mass	417.506 g·mol−1
log P	2.212
Acidity (pKa)	2.285
Basicity (pKb)	11.712
Pharmacology
ATC code	C09AA08 (WHO)
Routes of; administration	Oral
Legal status	UK: POM (Prescription only);
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.^[1]^[2]

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It was patented in 1982 and approved for medical use in 1990.^[3]

Chemistry