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Cimlanod

Chemical compound From Wikipedia, the free encyclopedia

Cimlanod (development codes CXL-1427 and BMS-986231) is an experimental drug for the treatment of acute decompensated heart failure. It was discovered by Cardioxyl Pharmaceuticals, which was acquired by Bristol-Myers Squibb. It is a precursor of nitroxyl.[1]

Legal status
  • Investigational
Quick facts Legal status, Identifiers ...
Cimlanod
Legal status
Legal status
  • Investigational
Identifiers
  • N-Hydroxy-5-methylfuran-2-sulfonamide
CAS Number
PubChem CID
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KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC5H7NO4S
Molar mass177.17 g·mol−1
3D model (JSmol)
  • CC1=CC=C(O1)S(=O)(=O)NO
  • InChI=1S/C5H7NO4S/c1-4-2-3-5(10-4)11(8,9)6-7/h2-3,6-7H,1H3
  • Key:LIXKIXWSKOENAB-UHFFFAOYSA-N
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Cimlanod is a prodrug of CXL-1020.[2]

A preliminary study showed efficacy in patients with class III and IV heart failure.[3] A phase II clinical trial was completed in 2016.[4]

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