Cladophialophora bantiana

Cladophialophora bantiana can cause infection in several species of animals including cats,^[10] dogs,^[11] and humans.^[12] However, it is very rare to find it in non-mammalian species.^[12] In one case in a dog, C. bantiana was identified as the causative agent of eumycetoma.^[11] It has been known to cause systemic phaeohyphomycosis in both cats and dogs.^[10]

Cladophialophora bantiana is known to cause a cerebral phaeohyphomycosis affecting the central nervous system in humans.^[13] It is unique in that it causes primary cerebral infection where the first symptoms of disease are of neurological nature, rather than disseminated.^[9] It is hypothesized that predilection of this species for the central nervous system is due to the presence of melanin, which may be able to cross the blood–brain barrier.^[3] However, this is unlikely since fungal melanin is structurally and biochemically different from human melanin and other species of highly pigmented fungi do not show neurotropism.^[3] It has also been suggested that the presence of introns in the 18S rDNA subunit of Cladophialophora may be related to the preference of C. bantiana for the CNS, however more research is required to determine the mechanism of this.^[14]

Radiologically, the intrafungal cerebral abscesses of C. bantiana are known as “the great mimickers” and may be difficult to distinguish from high grade gliomas, lymphoma, or metastatic cancer. Contrast-enhanced images show irregular heterogeneous lesions with significant surrounding edema.^[7]

In a review of 101 cases of phaeohyphomycosis by Revankar et al., C. bantiana was the causal agent responsible for 48% of cases. It most often manifests as brain abscesses in immunocompetent people, however meningitis and myelitis were observed in a limited number of cases.^[3] Although the majority of the patients were immunocompetent (73%), infection is also commonly seen in immunocompromised patients.^[13] Clinical symptoms of infection are varied and can include headache, seizure, arm pain, and ataxia.^[1] The mortality rate is about 70%, with better outcomes observed in patients who underwent complete excision of the abscess.^[13] Since the majority of patients infected were immunocompetent, the means of exposure to the fungi is still unclear. However, inhalation is the likely route of entrance.^[8]

Cases of infection are most commonly found in subtropical regions with high average humidity although cases have also been identified in the US, Canada and the UK.^[12] Cases from regions with hot, arid climate are rare.^[12] It has also been suggested to occupations with high exposure to dust and dirt such as farming and gardening are associated with higher risk of infection.^[12]

Since infection is very rare, there is no standard therapy for treatment of C. bantiana phaeohyphomycosis.

In 2021, the European Confederation of Medical Mycology, the International Society for Human and Animal Mycology, and the American Society for Microbiology created guidelines for rare mold infections, which includes C. bantiana. Current recommendations conclude that liposomal amphotericin B alone or in combination with an azole and/or echinocandin or voriconazole monotherapy is supported as first-line therapy. 5-Fluorocytosine can be used in combination with the other recommend antifungals, however, it has little supportive data.^[15] In addition, surgical resection of the fungal abscess is often necessary. Treatments utilizing only one of these approaches have had higher fatality rates, and the best outcomes are reported in cases utilizing both surgical and antifungal therapy; however, even with this approach, mortality remains high.^[16]