Stafford-Johnson has worked on filming several productions for RTÉ and the BBC, winning several awards for his work. He specialised in filming big cats and worked as a cameraman on the landmark BBC series Planet Earth.
He has filmed and presented several episodes of BBC's long running Natural World series. In 2011 he presented the episode "A Tiger Called Broken Tail", and the following year he presented "Queen of the Tigers." 2013 saw him present "Meet the Monkeys." In 2015 he narrated "Ireland’s Wild River: The Mighty Shannon" about the River Shannon.
In 2020 he presented a two-part wildlife programme titled "Wild Cuba: A Caribbean Journey".[4]
Along with his work on Natural World, Stafford-Johnson has co-presented Wild UK[5] and presented "Wild Ireland: Edge of the World" in 2017. In 2019 he presented "Animal Babies: First year on Earth".[6]
In 2021, he returned to his home in Ireland to create a wild garden, a series filmed for the BBC as The Wild Gardener.[7]