Commercially useful enzymes

A curated set of 510 CUEs was developed using publicly available information and categorized into nine broad application areas based on their functional roles. Through homology-based analysis of ten publicly available metagenomic datasets, several novel CUEs with homology to the curated set were discovered.

This approach led to the creation of the Metagenomic BioMining Engine (MetaBioME), a platform designed for the computational identification of homologs of known CUEs from metagenomic data. MetaBioME provides a resource for uncovering novel homologs of existing CUEs and identifying previously unknown enzymes, which can serve as leads for experimental validation. The platform is accessible online at MetaBioME.^[2]

• Sharma, VK; Kumar, N; Prakash, T; Taylor, TD (January 2010). "MetaBioME: a database to explore commercially useful enzymes in metagenomic datasets". Nucleic Acids Res. 38 (Database issue): D468–72. doi:10.1093/nar/gkp1001. PMC 2808964. PMID 19906710.

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