Complement component 1s

C1S
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ELV, 1NZI, 4J1Y, 4LMF, 4LOR, 4LOS, 4LOT
Identifiers
Aliases	C1S, EDSPD2, complement C1s
External IDs	OMIM: 120580; MGI: 3644269; HomoloGene: 1314; GeneCards: C1S; OMA:C1S - orthologs
EC number	3.4.21.42
Gene location (Human)
Chr.	Chromosome 12 (human)
End	7,071,032 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,613,044 bp
RNA expression pattern
	Top expressed in
	pericardium; ; right lobe of liver; ; parietal pleura; ; right ovary; ; gallbladder; ; left ovary; ; gastric mucosa; ; tibial nerve; ; left uterine tube; ; synovial joint;
	Top expressed in
	muscle of thigh; ; morula; ; embryo; ; white adipose tissue; ; bone marrow; ; adrenal gland; ; urinary bladder; ; ovary; ; lens; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; metal ion binding; identical protein binding; serine-type endopeptidase activity;
Cellular component	blood microparticle; extracellular exosome; extracellular region; extracellular space;
Biological process	proteolysis; complement activation, classical pathway; immune system process; innate immune response; complement activation, lectin pathway; complement activation; regulation of complement activation;
	Sources:Amigo / QuickGO
Orthologs
	716
	317677
	ENSG00000182326
	ENSMUSG00000079343
	P09871
	Q8CFG8
	NM_001734; NM_201442; NM_001346850
	NM_173864
	NP_001333779; NP_001725; NP_958850
	NP_776289
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system. C1s is part of the C1 complex.^[5]^[6]^[7]^[8] In humans, it is encoded by the C1S gene.^[9]