Contezolid

Contezolid (trade name Youxitai) is an antibiotic of the oxazolidinone class.^[1][2] It is effective against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pyogenes, Streptococcus agalactiae, and other bacteria.^[3]

Trade namesYouxitai

Other namesMRX-I

Legal status

• Rx in China

CAS Number

• 1112968-42-9

Quick facts Clinical data, Trade names ...

Contezolid

Clinical data
Trade names	Youxitai
Other names	MRX-I
Legal status
Legal status	Rx in China
Identifiers
IUPAC name (5S)-5-[(1,2-oxazol-3-ylamino)methyl]-3-[2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridin-1-yl)phenyl]-1,3-oxazolidin-2-one
CAS Number	1112968-42-9
PubChem CID	25184541
IUPHAR/BPS	10795
DrugBank	DB12796
ChemSpider	34217570
UNII	B669M62ELP
KEGG	D11297
ChEMBL	ChEMBL3287379
CompTox Dashboard (EPA)	DTXSID901353186
Chemical and physical data
Formula	C18H15F3N4O4
Molar mass	408.337 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN(C=CC1=O)C2=C(C=C(C(=C2F)F)N3C[C@@H](OC3=O)CNC4=NOC=C4)F
InChI InChI=1S/C18H15F3N4O4/c19-12-7-13(15(20)16(21)17(12)24-4-1-10(26)2-5-24)25-9-11(29-18(25)27)8-22-14-3-6-28-23-14/h1,3-4,6-7,11H,2,5,8-9H2,(H,22,23)/t11-/m0/s1 Key:SULYVXZZUMRQAX-NSHDSACASA-N

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In 2021, it was approved by the National Medical Products Administration of China for the treatment of complicated skin and soft tissue infections (cSSTI).^[3][4]

A prodrug of contezolid, contezolid acefosamil, which is formulated for IV administration^[5] is in Phase III clinical trials for diabetic foot infection.^[6]