Contryphan

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1dfy , 1dfz , 1dg0 , 1nxn , 1qfb

Contryphan
Contryphan
	NMR structure of Contryphan-Vn. The peptide backbone is depicted by a curved tube while the amino acid side-chains are represented by capped sticks. Carbon atoms are colored grey, nitrogen atoms blue, oxygen atoms red, and sulfur atoms yellow.; .
Identifiers
Symbol	Contryphan_CS
Pfam	PF02950
InterPro	IPR011062
PROSITE	PS60027
SCOP2	2cco / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1dfy , 1dfz , 1dg0 , 1nxn , 1qfb

SymbolContryphan_CS

The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation.^[2] In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2."^[3]

Peptide	Sequence	Species	Reference
Des(Gly1)contryphan-R	COwEPWC-NH2	C. radiatus	^[4]
Contryphan-R	GCOwEPWC-NH2	Conus radiatus	^[4]
Bromocontyphan-R	GCOwEPXC-NH2	C. radiatus	^[5]
Contryphan-Sm	GCOwQPWC-NH2	Conus stercusmuscarum	^[6]
Contryphan-P	GCOwDPWC-NH₂	C. purpurascens	^[6]
Contryphan-R/Tx	GCOwEPWC-NH2	Conus textile	^[6]
Contryphan-Tx	GCOWQPYC-NH2	Conus textile	^[6]
Contryphan-Vn	GDCPwKPWC-NH₂	Conus ventricosus	^[7]
Leu-contryphan-P	GCVlLPWC-OH	Conus purpurascens	^[8]
Leu-contryphan-Tx	CVlYPWC-NH₂	Conus textile	^[6]
Glaconryphan-M	NγSγCPWHPWC-NH₂	Conus marmoreus	^[2]

Mechanism of toxicity