In 1897 she married Edward C. Davis and the couple spent their two-year honeymoon in New Mexico and Arizona.[4] Davis painted on the trip, depicting Navajo and Hopi in portraits and sacred ceremonies. She was the first to paint Hopi snake dancers in their ceremonial wear and her paintings are known for their historic and ethnographic qualities.[5][6][7] After the Davis' honeymoon, the couple relocated to Chicago, Illinois, where Davis exhibited at the Chicago Art Institute and at Moulton's Gallery with 22 oil paintings primarily featuring the Hopi Indians.[2][4][6] In 1898, she exhibited at the Trans-Mississippi Exposition in Omaha, Nebraska. She painted a portrait of President William McKinley which was commissioned for the Westminster Central Hall in London, England.[5]
In 1905 she settled in Cincinnati, Ohio and was a member of the Cincinnati Women's Art Club.[5] In 1913, she was the first women to be admitted to the all-male life class of the Cincinnati Art Club.[2]