+ 2 reduced
ferredoxin + H+
Corticosterone 18-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Corticosterone 18-monooxygenase (EC 1.14.15.5) is an enzyme that catalyzes the chemical reaction
| Corticosterone 18-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.5 | ||||||||
| CAS no. | 37256-75-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Corticosterone is an oxidoreductase which uses molecular oxygen to insert a hydroxy group at position 18 of the steroid. It requires adrenal ferredoxin to transfer electrons to the cytochrome P450 active site.[1][2] The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating). Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase.[3] This enzyme is part of the pathway which converts corticosterone to aldosterone.[4]
