Corymine
Chemical compound, neurotoxin
From Wikipedia, the free encyclopedia
Corymine, also known as NSC381080, is a natural alkaloid found in Hunteria zeylanica.
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| IUPAC name
Methyl (15E)-15-ethylidene-18-hydroxy-3-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.02,13.04,9.010,17]icosa-4,6,8-triene-17-carboxylate | |
Other names
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| Identifiers | |
3D model (JSmol) |
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| Properties | |
| C22H26N2O4 | |
| Molar mass | 382.460 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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This compound acts as a glycine antagonist and could therefore, be classed as a neurotoxin.
Occurrence
Corymine and many other indole alkaloids can be isolated from parts of the Hunteria zeylanica plant.
The plant also contains other similar alkaloids, such as[1]
- 3-epi-dihydrocorymine
- 3-epi-dihydrocorymine 3-acetate
- 3-epi-dihydrocorymine 17-acetate
- norisocorymine
Toxicity
Corymine and related alkaloids can act as convulsants.[2]
Tests on Xenopus occyte species have shown that corymine can decrease glycine's action at the inhibitory glycine receptors.[3] These same tests have revealed that Corymine can reduce the response of receptors to GABA,[3] the primary inhibitory neurotransmitter.
Other experiments have shown that corymine can potentiate convulsions induced by strychnine, a potent glycine antagonist.[4] This was also observed in mice.[5]