Creative works set in Charleston, South Carolina
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- Porgy (1925), by DuBose Heyward, adapted into a play in 1927.
- Several books by Citadel alumnus and novelist Pat Conroy (d. 2016), such as The Lords of Discipline (1980) set from 1963–'67, and (based on Conroy's experiences as a cadet at The Citadel) and South of Broad (a #1 2009 New York Times Best Seller).
- British author Clive Barker's novel Galilee 1998
- Harry Turtledove's Southern Victory Series (1997-2007), an alternate history series about a Confederacy that won the Civil War
- Italian author Rafael Sabatini's novel The Carolinian
- Grace Peixotto and her bordello, the Big Brick at 11 Beresford Street in Charleston, are said to have been the inspiration for Belle Watling and her brothel in Margaret Mitchell's Gone With the Wind (1936).[7]
- A #1 New York Times Best Seller in 1991 (and the best selling novel of 1991) Scarlett, is the sequel to Gone with the Wind. In fact, the late Alexandra Ripley, the author of Scarlett and a Charleston native, derived inspiration from the city for her novel Charleston (1981) and its sequel On Leaving Charleston.
- The novel Werewolf Smackdown by Mario Acevedo is set in Charleston.[8]
- The novels Dreams of Sleep, Rich in Love, and The Fireman's Fair were written by Josephine Humphreys, a native of Charleston. All are set in Charleston and the Charleston area. Rich in Love (1993) was filmed on Mount Pleasant and in Charleston.
- Virals, Seizure, Code, Exposure, and Terminal (2010–15) by Kathy Reichs are set in Charleston.
- Celia Garth, a Revolutionary era novel by Gwen Bristow
- Rick Riordan's 2012 hit teen book Mark of Athena, part of the Percy Jackson/Heroes of Olympus series has several scenes set in Charleston like Fort Sumter.
- Sue Monk Kidd's 2014 novel The Invention of Wings (a #1 New York Times Best Seller). The book's story is partially situated in Charleston, the birthplace of Sarah Grimké, who also inspired the main characters of the novel.[9]
- North and South series of books by John Jakes, was partially set in Charleston. North and South reached #1 on the New York Times Best Seller list in 1982.
- Charleston by Alexandra Ripley was set in the town.
- The Trust by Sean Keefer, a legal thriller, is set in and around Charleston.