Cruentaren

Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta.^[1] There are two isomers (cruentaren A and B) have been isolated.^[2] They each have a molecular formula of C₃₃H₅₁NO₈ and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro,^[3] including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.