In 878, when Emperor Xizong decided to remove the chancellors Zheng Tian and Lu Xi over a violent argument that Zheng and Lu had with each other, both Cui Hang and Doulu Zhuan were made chancellors to succeed Zheng and Lu, with the designation Tong Zhongshu Menxia Pingzhangshi (同中書門下平章事). After Lu was restored to the chancellorship in 879, though, Lu was clearly the leader among the chancellors, and Doulu was described as simply following Lu's lead on policies. Further, when Cui would have policy suggestions, Doulu often stopped him from presenting them.[7] There was one major policy decision that he prevailed on — when the warlord Wang Jingchong, who controlled Chengde Circuit (成德, headquartered in modern Shijiazhuang, Hubei), also sought to have the imperial government grant him Yiwu Circuit (義武, headquartered in modern Baoding, Hubei), Cui, pointing out that Chengde, in conjunction with other warlord-controlled circuits Weibo (魏博, headquartered in modern Handan, Hubei) and Lulong (盧龍, headquartered in modern Beijing), would be even harder to control, refused.[6]
By late 880, the major agrarian rebel Huang Chao captured the eastern capital Luoyang and the capital Chang'an. Doulu and Cui suggested sending forces to defend Tong Pass to stop Huang's advance toward Chang'an, but both of them were also suggesting that the contingency plan made by the powerful eunuch Tian Lingzi — that Emperor Xizong flee to the Sanchuan region (三川, i.e., modern Sichuan, Chongqing, and southern Shaanxi) be implemented. After Huang captured Tong Pass and approached Chang'an, Emperor Xizong fled toward Xichuan Circuit (西川, headquartered in modern Chengdu, Sichuan), where Tian's brother Chen Jingxuan was military governor.[8] Doulu and Cui, for reasons unknown, were unable to follow Emperor Xizong's flight, and they, along with the former chancellor Liu Ye, hid at the mansion of the general Zhang Zhifang, who had outwardly submitted to Huang (who declared himself the emperor of a new state of Qi) upon Huang's entry into Chang'an but was hiding many Tang officials at his mansion. As Qi forces sought to find hiding Tang officials, however, Liu, Doulu, and Cui tried to flee, but were captured. Refusing to submit to Huang, they were executed.[8][9]