Cyazofamid
Chemical compound
From Wikipedia, the free encyclopedia
Cyazofamid is a fungicide that is highly-specific in controlling oomycete plant pathogens such as Phytophthora infestans, the organism which causes late blight in potato. Its mode of action is thought to involve binding to the Qi center of Coenzyme Q – cytochrome c reductase.[3][4]
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| Names | |
|---|---|
| IUPAC name
4-chloro-2-cyano-N,N-dimethyl-5-(4-methylphenyl)imidazole-1-sulfonamide | |
| Other names
IKF 916 | |
| Identifiers | |
3D model (JSmol) |
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| 9064229 | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.111.751 |
| EC Number |
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| KEGG | |
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
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| Properties[1] | |
| C13H13ClN4O2S | |
| Molar mass | 324.78 g·mol−1 |
| Density | 1.45 g/cm3 |
| Melting point | 152.7 °C |
| 0.107 mg/L (20 °C) | |
| log P | 3.2 |
| Hazards[2] | |
| GHS labelling: | |
 | |
| Warning | |
| H410 | |
| P273, P391, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Cyazofamid is most often sold under the brand name Ranman.[5]
Synthesis
Processes to manufacture cyazofamid were disclosed in patents from Ishihara Sangyo Kaisha, Ltd.[6] An acetophenone derivative was first treated with aqueous glyoxal and hydroxylamine to form an oxime-substituted imidazole ring system. This intermediate was treated with thionyl chloride and disulfur dichloride to convert the oxime to a cyano group and chlorinate the imidazole in the position next to the phenyl ring. Finally, treatment with dimethylsulfamoyl chloride gave cyazofamid, with the desired regiochemistry. This placed the sulfamoyl group on the nitrogen adjacent to the phenyl ring rather than the chlorine atom. The structure of the fungicide has been confirmed by X-ray crystallography.[7]
