Cychlorphine

Cychlorphine (N-Propionitrile chlorphine) is a synthetic opioid chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA.^[1] It has been found in Canada as of September 2025.^[2] It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published.^[3][4][5] It is not a structural analog of morphine, despite the similar name. Instead, it is an orphine.^[6]

Legal status

• DE: NpSG (Industrial and scientific use only)

CAS Number

• 16145-71-4

PubChem CID

• 201662

ChemSpider

• 174605

Quick facts Legal status, Identifiers ...

Cychlorphine

Legal status
Legal status	DE: NpSG (Industrial and scientific use only)
Identifiers
CAS Number	16145-71-4
PubChem CID	201662
ChemSpider	174605
ECHA InfoCard	100.006.468
Chemical and physical data
Formula	C23H25ClN4O
Molar mass	408.93 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C1=CC=C(C=C1)Cl)N2CCC(CC2)N3C4=CC=CC=C4N(C3=O)CCC#N
InChI InChI=1S/C23H25ClN4O/c1-17(18-7-9-19(24)10-8-18)26-15-11-20(12-16-26)28-22-6-3-2-5-21(22)27(23(28)29)14-4-13-25/h2-3,5-10,17,20H,4,11-12,14-16H2,1H3 Key:SWWAVNFEFVMDAG-UHFFFAOYSA-N

Close

At least 5 people have died from a cychlorphine overdose in England in 2025.^[7] Furthermore, it has been detected as the sole active opioid in fake pharmaceutical opioid preparations that are supposed to contain hydromorphone or oxycodone, further increasing the risk of accidental overdoses.^[2]

It was added to the German NpSG in December 2025.^[8]