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Cyclin-dependent kinase 10

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[5][6][7]

AliasesCDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
End89,696,354 bp[1]
Quick facts CDK10, Identifiers ...
CDK10
Identifiers
AliasesCDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDsOMIM: 603464; MGI: 2448549; HomoloGene: 55769; GeneCards: CDK10; OMA:CDK10 - orthologs
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.11.22
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098533
NM_001160367
NM_003674
NM_052987
NM_052988

NM_194444
NM_194446

RefSeq (protein)

NP_001092003
NP_001153839
NP_443713
NP_443714

NP_919426
NP_919428

Location (UCSC)Chr 16: 89.68 – 89.7 MbChr 8: 123.95 – 123.96 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[7]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.[8]

References

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