Cyclin-dependent kinase 11A

Cyclin-dependent kinase 11A is an enzyme that in humans is encoded by the CDK11A gene (previously CDC2L2).^[5][6][7]

AliasesCDK11A, CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE, p58GTA, cyclin-dependent kinase 11A, cyclin dependent kinase 11A

External IDsOMIM: 116951; MGI: 88353; GeneCards: CDK11A

Chr.Chromosome 1 (human)^[1]

End1,724,357 bp^[1]

Quick facts CDK11A, Identifiers ...

CDK11A
Identifiers
Aliases	CDK11A, CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE, p58GTA, cyclin-dependent kinase 11A, cyclin dependent kinase 11A
External IDs	OMIM: 116951; MGI: 88353; GeneCards: CDK11A
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.22 ↗ ↗ ↗ ↗ 2.7.11.23 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.33 Start 1,702,379 bp[1] End 1,724,357 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 86.73 cM Start 155,624,854 bp[2] End 155,649,938 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve mucosa of transverse colon granulocyte spleen right hemisphere of cerebellum pituitary gland fundus right lung right lobe of thyroid gland right testis Top expressed in granulocyte tail of embryo neural layer of retina saccule genital tubercle otic placode ventricular zone otic vesicle epiblast body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity protein serine/threonine kinase activity protein kinase activity ATP binding nucleotide binding transferase activity protein binding cyclin-dependent protein serine/threonine kinase activity Cellular component nucleus cytoplasm Biological process regulation of transcription, DNA-templated phosphorylation cell cycle regulation of cell growth protein phosphorylation regulation of mRNA processing apoptotic process regulation of mitotic cell cycle mitotic cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 728642 12537 Ensembl ENSG00000008128 ENSMUSG00000029062 UniProt Q9UQ88 P24788 RefSeq (mRNA) NM_001313896 NM_001313982 NM_024011 NM_033527 NM_033529 NM_033532 NM_033534 NM_007661 NM_001347308 NM_001355567 NM_001355568 NM_001355569 RefSeq (protein) NP_001300825 NP_001300911 NP_076916 NP_277071 NP_001334237 NP_031687 NP_001342496 NP_001342497 NP_001342498 Location (UCSC) Chr 1: 1.7 – 1.72 Mb Chr 4: 155.62 – 155.65 Mb PubMed search [3] [4]
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This gene shares very high sequence identity with a neighboring gene, CDK11B. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis.^[7]