Cyclin-dependent kinase 13

Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene.^[5][6]

AliasesCDK13, CDC2L, CDC2L5, CHED, hcyclin-dependent kinase 13, cyclin dependent kinase 13, CHDFIDD

External IDsOMIM: 603309; MGI: 1916812; GeneCards: CDK13

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 7 (human)^[1]

Quick facts CDK13, Identifiers ...

CDK13
Identifiers
Aliases	CDK13, CDC2L, CDC2L5, CHED, hcyclin-dependent kinase 13, cyclin dependent kinase 13, CHDFIDD
External IDs	OMIM: 603309; MGI: 1916812; GeneCards: CDK13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EFQ
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.22 ↗ ↗ ↗ ↗ 2.7.11.23 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1 Start 39,950,121 bp[1] End 40,099,580 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A2 Start 17,884,900 bp[2] End 17,979,682 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell renal medulla visceral pleura pylorus nipple cardia endothelial cell ventral tegmental area inferior ganglion of vagus nerve parietal pleura Top expressed in genital tubercle tail of embryo spermatocyte Rostral migratory stream hand granulocyte spermatid thymus gastrula neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding RNA polymerase II CTD heptapeptide repeat kinase activity ATP binding cyclin binding cyclin-dependent protein serine/threonine kinase activity transcription factor binding protein kinase binding RNA binding Cellular component Golgi apparatus nuclear speck nuclear cyclin-dependent protein kinase holoenzyme complex cyclin K-CDK13 complex nucleus extracellular region extracellular space nucleoplasm chromosome cytosol cyclin/CDK positive transcription elongation factor complex ficolin-1-rich granule lumen cyclin-dependent protein kinase holoenzyme complex Biological process hemopoiesis phosphorylation of RNA polymerase II C-terminal domain phosphorylation mRNA processing multicellular organism development protein phosphorylation RNA splicing positive regulation of cell population proliferation viral process alternative mRNA splicing, via spliceosome regulation of mitotic nuclear division transcription elongation from RNA polymerase II promoter neutrophil degranulation positive regulation of transcription by RNA polymerase II negative regulation of stem cell differentiation positive regulation of transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8621 69562 Ensembl ENSG00000065883 ENSMUSG00000041297 UniProt Q14004 Q69ZA1 RefSeq (mRNA) NM_003718 NM_031267 NM_001081058 NM_027118 RefSeq (protein) NP_003709 NP_112557 NP_001074527 NP_081394 Location (UCSC) Chr 7: 39.95 – 40.1 Mb Chr 13: 17.88 – 17.98 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.^[6]