D-alanine—D-serine ligase

D-Alanine—D-serine ligase (EC 6.3.2.35, VanC, VanE, VanG) is an enzyme with systematic name D-alanine:D-serine ligase (ADP-forming).^{[1][2][3][4][5]} This enzyme catalyses the following chemical reaction

D-alanine + D-serine + ATP ${\displaystyle \rightleftharpoons }$ D-alanyl-D-serine + ADP + phosphate

The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide.