DAA-1106

DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at the GABAA receptor. It has anxiolytic effects in animal studies.^[1][2][3] DAA-1106 has a sub-nanomolar binding affinity (K_i) of 0.28 nM, and has been used extensively in its ³H or ¹¹C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease.^{[4][5][6][7][8][9]}

CAS Number

• 220551-92-8

PubChem CID

• 10430788

ChemSpider

• 8606215

UNII

• 3A8IVT5Q3P

Quick facts Identifiers, CAS Number ...

DAA-1106

Identifiers
IUPAC name N-(2-Phenoxy-5-fluorophenyl)-N-(2,5-dimethoxybenzyl)acetamide
CAS Number	220551-92-8
PubChem CID	10430788
ChemSpider	8606215
UNII	3A8IVT5Q3P
CompTox Dashboard (EPA)	DTXSID30439829
Chemical and physical data
Formula	C23H22FNO4
Molar mass	395.430 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC(CN(C(C)=O)C2=CC(F)=CC=C2OC3=CC=CC=C3)=C(O[11CH3])C=C1
InChI InChI=1S/C23H22FNO4/c1-16(26)25(15-17-13-20(27-2)10-12-22(17)28-3)21-14-18(24)9-11-23(21)29-19-7-5-4-6-8-19/h4-14H,15H2,1-3H3https://drugs.ncats.io/drug/696AIN172A# Key:DCRZYADKQRHHSF-UHFFFAOYSA-N
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DAA-1106 is used in combination with positron emission tomography (PET) scanning to examine neuroinflammation in vivo.^[10]