DARS2

DARS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AH6
Identifiers
Aliases	DARS2, ASPRS, LBSL, MT-ASPRS, aspartyl-tRNA synthetase 2, mitochondrial, mtAspRS
External IDs	OMIM: 610956; MGI: 2442510; HomoloGene: 7093; GeneCards: DARS2; OMA:DARS2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,858,808 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,898,228 bp
RNA expression pattern
	Top expressed in
	gonad; ; rectum; ; right adrenal gland; ; ventricular zone; ; mucosa of transverse colon; ; right adrenal cortex; ; islet of Langerhans; ; testicle; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	epiblast; ; ventricular zone; ; right kidney; ; primitive streak; ; proximal tubule; ; tail of embryo; ; blastocyst; ; embryo; ; Paneth cell; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; tRNA binding; ligase activity; aspartate-tRNA(Asn) ligase activity; protein binding; ATP binding; protein homodimerization activity; nucleic acid binding; aspartate-tRNA ligase activity;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion; nucleus;
Biological process	tRNA aminoacylation; tRNA aminoacylation for protein translation; protein biosynthesis; mitochondrial asparaginyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	55157
	226539
	ENSG00000117593
	ENSMUSG00000026709
	Q6PI48
	Q8BIP0
	NM_018122; NM_001365212; NM_001365213
	NM_172644
	NP_060592; NP_001352141; NP_001352142; NP_060592.2
	NP_766232
	Wikidata
View/Edit Human	View/Edit Mouse

PDBOrtholog search: PDBe RCSB

AliasesDARS2, ASPRS, LBSL, MT-ASPRS, aspartyl-tRNA synthetase 2, mitochondrial, mtAspRS

External IDsOMIM: 610956; MGI: 2442510; HomoloGene: 7093; GeneCards: DARS2; OMA:DARS2 - orthologs

Chr.Chromosome 1 (human)^[1]

Aspartyl-tRNA Synthetase 2, Mitochondrial is an enzyme which is encoded by the gene DARS2.^[5]

[1]

[2]

[3]

[4]

[5]

DARS2

Function

Clinical significance

Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)

References

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