DCPS (gene)

PDBOrtholog search: PDBe RCSB

AliasesDCPS, DCS1, HINT-5, HINT5, HSL1, ARS, HSPC015, decapping enzyme, scavenger

External IDsOMIM: 610534; MGI: 1916555; HomoloGene: 32202; GeneCards: DCPS; OMA:DCPS - orthologs

Chr.Chromosome 11 (human)^[1]

DCPS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ST0, 1ST4, 1XML, 1XMM, 3BL7, 3BL9, 3BLA, 4QDE, 4QDV, 4QEB
Identifiers
Aliases	DCPS, DCS1, HINT-5, HINT5, HSL1, ARS, HSPC015, decapping enzyme, scavenger
External IDs	OMIM: 610534; MGI: 1916555; HomoloGene: 32202; GeneCards: DCPS; OMA:DCPS - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 126,304,060 bp[1] End 126,350,005 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 35,035,704 bp[2] End 35,087,357 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver oocyte muscle of thigh granulocyte secondary oocyte gallbladder gonad mucosa of transverse colon stromal cell of endometrium spleen Top expressed in yolk sac ventricular zone epiblast embryo otic placode embryo endocardial cushion medial ganglionic eminence right kidney primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function m7G(5')pppN diphosphatase activity protein binding hydrolase activity RNA 7-methylguanosine cap binding exoribonuclease activity Cellular component cytoplasm mitochondrion nucleus nucleoplasm P-body cytosol Biological process mRNA cis splicing, via spliceosome negative regulation of programmed cell death mRNA processing nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay cellular response to menadione RNA splicing exonucleolytic catabolism of deadenylated mRNA RNA phosphodiester bond hydrolysis, exonucleolytic deadenylation-dependent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28960 69305 Ensembl ENSG00000110063 ENSMUSG00000032040 UniProt Q96C86 Q9DAR7 RefSeq (mRNA) NM_014026 NM_001350236 NM_027030 RefSeq (protein) NP_054745 NP_001337165 NP_081306 Location (UCSC) Chr 11: 126.3 – 126.35 Mb Chr 9: 35.04 – 35.09 Mb PubMed search [3] [4]
Wikidata
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Scavenger mRNA decapping enzyme (DcpS) N-terminal
crystal structure of mrna decapping enzyme (dcps) from mus musculus at 1.83 a resolution
Identifiers
Symbol	DcpS
Pfam	PF05652
InterPro	IPR008594
SCOP2	1st4 / SCOPe / SUPFAM
Available protein structures: PDB   IPR008594 PF05652 (ECOD; PDBsum)   AlphaFold IPR008594 PF05652

Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.^[5][6][7]

The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP).^[8] The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues.^[9] The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.