DCTN5

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.^[5]

AliasesDCTN5, dynactin subunit 5

External IDsOMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs

Chr.Chromosome 16 (human)^[1]

End23,677,472 bp^[1]

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DCTN5
Identifiers
Aliases	DCTN5, dynactin subunit 5
External IDs	OMIM: 612962; MGI: 1891689; HomoloGene: 10998; GeneCards: DCTN5; OMA:DCTN5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 23,641,466 bp[1] End 23,677,472 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 121,732,264 bp[2] End 121,748,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans rectum stromal cell of endometrium smooth muscle tissue monocyte mucosa of esophagus ganglionic eminence lymph node epithelium of colon mucosa of transverse colon Top expressed in dentate gyrus of hippocampal formation granule cell right kidney granulocyte superior frontal gyrus medial ganglionic eminence yolk sac pituitary gland tail of embryo cumulus cell blood More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol centrosome nuclear membrane chromosome, centromeric region cytoskeleton kinetochore nucleoplasm chromosome Biological process endoplasmic reticulum to Golgi vesicle-mediated transport aorta development ventricular septum development antigen processing and presentation of exogenous peptide antigen via MHC class II coronary vasculature development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84516 59288 Ensembl ENSG00000166847 ENSMUSG00000030868 UniProt Q9BTE1 Q9QZB9 RefSeq (mRNA) NM_001199011 NM_001199743 NM_032486 NM_021608 RefSeq (protein) NP_001185940 NP_001186672 NP_115875 NP_067621 Location (UCSC) Chr 16: 23.64 – 23.68 Mb Chr 7: 121.73 – 121.75 Mb PubMed search [3] [4]
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This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5]