DDX10

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesDDX10, HRH-J8, DEAD-box helicase 10, Dbp4

External IDsOMIM: 601235; MGI: 1924841; HomoloGene: 20922; GeneCards: DDX10; OMA:DDX10 - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

DDX10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PL3
Identifiers
Aliases	DDX10, HRH-J8, DEAD-box helicase 10, Dbp4
External IDs	OMIM: 601235; MGI: 1924841; HomoloGene: 20922; GeneCards: DDX10; OMA:DDX10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.3 Start 108,665,058 bp[1] End 108,940,999 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 53,009,935 bp[2] End 53,159,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve testicle Achilles tendon right testis left testis gonad ganglionic eminence ventricular zone kidney tubule left uterine tube Top expressed in tail of embryo otic placode saccule genital tubercle Gonadal ridge epiblast primitive streak otic vesicle hair follicle maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component nucleolus cytoplasm Biological process RNA secondary structure unwinding anterior head development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1662 77591 Ensembl ENSG00000178105 ENSMUSG00000053289 UniProt Q13206 Q80Y44 RefSeq (mRNA) NM_004398 NM_029936 RefSeq (protein) NP_004389 NP_084212 Location (UCSC) Chr 11: 108.67 – 108.94 Mb Chr 9: 53.01 – 53.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.^[6]