DDX11
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
ATP-dependent DNA/RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.[5][6] DDX11 is found within chromosome 12’s repetitive region.[6] Its function as a helicase was determined from its structure.
Function
This helicase is then regulated by long noncoding RNA and its ability to dismantle DNA triplexes known.[7] It works best in the positive direction of already split DNA - commonly the duplex form.[7] DDX11's role in sister chromatid cohesion is an active area of research.[7]
Structure
The structure of DDX11 is shown in the image where α-helices (blue) and β sheets (green) surround the DEAH box (red). The possible E2 binding domain was depicted in beige, this binding allows for papillomaviruses to persist in cells.[7]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[5]
See also
- Warsaw breakage syndrome, genetic condition caused by mutation of the DDX11
