DDX39

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.^[5][6]

AliasesDDX39A, BAT1, BAT1L, DDX39, DDXL, URH49, DEAD-box helicase 39A, DExD-box helicase 39A

External IDsMGI: 1915528; HomoloGene: 68487; GeneCards: DDX39A; OMA:DDX39A - orthologs

Chr.Chromosome 19 (human)^[1]

End14,419,383 bp^[1]

Quick facts DDX39A, Identifiers ...

DDX39A
Identifiers
Aliases	DDX39A, BAT1, BAT1L, DDX39, DDXL, URH49, DEAD-box helicase 39A, DExD-box helicase 39A
External IDs	MGI: 1915528; HomoloGene: 68487; GeneCards: DDX39A; OMA:DDX39A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,408,798 bp[1] End 14,419,383 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,441,806 bp[2] End 84,453,521 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis granulocyte ventricular zone spleen lymph node mucosa of transverse colon appendix ganglionic eminence upper lobe of left lung Top expressed in primitive streak Paneth cell endothelial cell of lymphatic vessel hair follicle abdominal wall otic placode medullary collecting duct migratory enteric neural crest cell epiblast condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function helicase activity nucleotide binding protein binding nucleic acid binding hydrolase activity ATP binding ATPase activity identical protein binding RNA binding Cellular component membrane spliceosomal complex cytoplasm nucleus nucleoplasm nuclear speck nucleolus Biological process RNA splicing mRNA splicing, via spliceosome mRNA processing mRNA export from nucleus cellular response to DNA damage stimulus RNA secondary structure unwinding regulation of gene expression RNA export from nucleus termination of RNA polymerase II transcription mRNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10212 68278 Ensembl ENSG00000123136 ENSMUSG00000005481 UniProt O00148 Q8VDW0 RefSeq (mRNA) NM_001204057 NM_005804 NM_138998 NM_197982 NM_001363116 NM_001363117 RefSeq (protein) NP_005795 NP_932099 NP_001350045 NP_001350046 Location (UCSC) Chr 19: 14.41 – 14.42 Mb Chr 8: 84.44 – 84.45 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.^[6]