DEFB105A

Beta-defensin 105 is a protein that is encoded by the DEFB105A gene in humans.^[5][6][7]

AliasesDEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A

External IDsMGI: 1924924; HomoloGene: 17531; GeneCards: DEFB105A; OMA:DEFB105A - orthologs

Chr.Chromosome 8 (human)^[1]

End7,823,880 bp^[1]

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DEFB105A
Identifiers
Aliases	DEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A
External IDs	MGI: 1924924; HomoloGene: 17531; GeneCards: DEFB105A; OMA:DEFB105A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 7,821,004 bp[1] End 7,823,880 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.3 Start 19,161,947 bp[2] End 19,164,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle tissue cell blood somatic cell white blood cell monocyte renal cortex endometrium exocrine gland cervix Top expressed in zone of skin testicle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 245908 77674 Ensembl ENSG00000186562 ENSMUSG00000043787 UniProt Q8NG35 Q8K4N3 RefSeq (mRNA) NM_152250 NM_152802 RefSeq (protein) NP_689463 NP_690015 Location (UCSC) Chr 8: 7.82 – 7.82 Mb Chr 8: 19.16 – 19.16 Mb PubMed search [3] [4]
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Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: Alpha defensins, Beta defensins and Theta defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.^[7]