DEK (gene)

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PDBOrtholog search: PDBe RCSB
AliasesDEK, D6S231E, DEK proto-oncogene
DEK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDEK, D6S231E, DEK proto-oncogene
External IDsOMIM: 125264; MGI: 1926209; HomoloGene: 2593; GeneCards: DEK; OMA:DEK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134709
NM_003472

NM_025900

RefSeq (protein)

NP_001128181
NP_003463

NP_080176

Location (UCSC)Chr 6: 18.22 – 18.26 MbChr 13: 47.24 – 47.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human DEK gene encodes the DEK protein.[5][6]

This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[6]

Interactions

DEK interacts with TFAP2A.[7]

References

Further reading

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