DHX29

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection.^[6] This protein may also play a role in sensing virally derived cytosolic nucleic acids.^[7] Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.^[8]

DHX29 has been shown to interact with the eukaryotic small ribosomal subunit (40S) and eIF3.^{[9][10][11][12]}

• Eukaryotic translation
• DExD/H box proteins
• Ded1/DDX3