DLG2

DLG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BYG, 2HE2
Identifiers
Aliases	DLG2, PPP1R58, PSD-93, PSD93, chapsyn-110, discs large homolog 2, discs large MAGUK scaffold protein 2
External IDs	OMIM: 603583; MGI: 1344351; HomoloGene: 1046; GeneCards: DLG2; OMA:DLG2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	85,627,922 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	92,449,247 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; corpus callosum; ; inferior ganglion of vagus nerve; ; prefrontal cortex; ; right frontal lobe; ; entorhinal cortex; ; middle temporal gyrus; ; nucleus accumbens; ; hippocampus proper; ; Brodmann area 23;
	Top expressed in
	superior frontal gyrus; ; lateral septal nucleus; ; lobe of cerebellum; ; piriform cortex; ; dentate gyrus of hippocampal formation granule cell; ; olfactory tubercle; ; cerebellar vermis; ; anterior amygdaloid area; ; primary motor cortex; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanylate kinase activity; kinase binding; protein binding; ionotropic glutamate receptor binding; structural constituent of postsynaptic density;
Cellular component	postsynaptic membrane; cell projection; membrane; postsynaptic density; voltage-gated potassium channel complex; plasma membrane; synapse; axon; cell junction; basolateral plasma membrane; ionotropic glutamate receptor complex; juxtaparanode region of axon; cytosol; neuromuscular junction; neuron projection; postsynaptic density membrane; glutamatergic synapse; axon cytoplasm;
Biological process	chemical synaptic transmission; receptor localization to synapse; negative regulation of phosphatase activity; receptor clustering; nervous system development; establishment or maintenance of epithelial cell apical/basal polarity; sensory perception of pain; GDP metabolic process; GMP metabolic process; MAPK cascade; cellular response to potassium ion; cell-cell adhesion; maintenance of postsynaptic density structure; anterograde axonal protein transport; retrograde axonal protein transport; neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	1740
	23859
	ENSG00000150672
	ENSMUSG00000052572
	Q15700
	Q91XM9
NM_001142699; NM_001142700; NM_001142702; NM_001206769; NM_001300983;
	NM_001364; NM_001351274; NM_001351275; NM_001351276; NM_001377966; NM_001377967; NM_001377968; NM_001377970; NM_001377971; NM_001377972; NM_001377973; NM_001377974; NM_001377975; NM_001377976; NM_001377977; NM_001377978; NM_001377979; NM_001377980; NM_001377981; NM_001377982; NM_001377983; NM_175892
	NM_001243046; NM_001243047; NM_011807
NP_001136171; NP_001136172; NP_001136174; NP_001193698; NP_001287912;
	NP_001355; NP_001338203; NP_001338204; NP_001338205; NP_001364895; NP_001364896; NP_001364897; NP_001364899; NP_001364900; NP_001364901; NP_001364902; NP_001364903; NP_001364904; NP_001364905; NP_001364906; NP_001364907; NP_001364908; NP_001364909; NP_001364910; NP_001364911; NP_001364912
	NP_001229975; NP_001229976; NP_035937
	Wikidata
View/Edit Human	View/Edit Mouse

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.^[5]^[6]