DLGAP1

DLGAP1
Identifiers
Aliases	DLGAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP, discs large homolog associated protein 1, DLG associated protein 1
External IDs	OMIM: 605445; MGI: 1346065; HomoloGene: 31258; GeneCards: DLGAP1; OMA:DLGAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	4,455,307 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	71,128,408 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; primary visual cortex; ; prefrontal cortex; ; pons; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; parietal lobe; ; superior frontal gyrus; ; right frontal lobe;
	Top expressed in
	piriform cortex; ; subiculum; ; primary motor cortex; ; cingulate gyrus; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; lateral septal nucleus; ; cerebellar vermis; ; lobe of cerebellum; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein domain specific binding; protein-containing complex binding;
Cellular component	cell junction; postsynaptic membrane; postsynaptic density; membrane; plasma membrane; synapse; cellular component;
Biological process	signaling; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9229
	224997
	ENSG00000170579
	ENSMUSG00000003279
	O14490
	Q9D415
NM_001003809; NM_001242761; NM_001242762; NM_001242763; NM_001242764;
	NM_001242765; NM_001242766; NM_001308390; NM_004746
NM_001128180; NM_001128181; NM_027712; NM_177639; NM_001347411;
	NM_001347412; NM_001347413; NM_001347414; NM_001360665
NP_001003809; NP_001229690; NP_001229691; NP_001229692; NP_001229693;
	NP_001229694; NP_001229695; NP_001295319; NP_004737
NP_001121652; NP_001121653; NP_001334340; NP_001334341; NP_001334342;
	NP_001334343; NP_081988; NP_808307; NP_001347594
	Wikidata
View/Edit Human	View/Edit Mouse

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.^[5]

AliasesDLGAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP, discs large homolog associated protein 1, DLG associated protein 1

External IDsOMIM: 605445; MGI: 1346065; HomoloGene: 31258; GeneCards: DLGAP1; OMA:DLGAP1 - orthologs

Chr.Chromosome 18 (human)^[1]

End4,455,307 bp^[1]

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[2]

[3]

[4]

DLGAP1

Function

Interactions

References

Further reading

Related Articles

Related Articles

"Intramolecular interactions regulate SAP97 binding to GKAP"

"GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules"

"Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein"

"Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90"

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"

"p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP"