DLX6

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.^[5][6]

AliasesDLX6, distal-less homeobox 6

External IDsOMIM: 600030; MGI: 101927; HomoloGene: 87855; GeneCards: DLX6; OMA:DLX6 - orthologs

Chr.Chromosome 7 (human)^[1]

End97,011,040 bp^[1]

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DLX6
Identifiers
Aliases	DLX6, distal-less homeobox 6
External IDs	OMIM: 600030; MGI: 101927; HomoloGene: 87855; GeneCards: DLX6; OMA:DLX6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.3 Start 97,005,553 bp[1] End 97,011,040 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A1|6 2.83 cM Start 6,863,334 bp[2] End 6,868,568 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell testicle endometrium nucleus accumbens caudate nucleus putamen gonad oocyte sperm endothelial cell Top expressed in superior frontal gyrus Apical ectodermal ridge medial ganglionic eminence lateral septal nucleus hair genital tubercle primary visual cortex olfactory tubercle olfactory bulb dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus Biological process skeletal system development regulation of transcription, DNA-templated nervous system development embryonic limb morphogenesis epithelial cell differentiation inner ear morphogenesis anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation roof of mouth development head development multicellular organism development regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1750 13396 Ensembl ENSG00000006377 ENSMUSG00000029754 UniProt P56179 P70397 RefSeq (mRNA) NM_005222 NM_010057 RefSeq (protein) NP_005213 NP_034187 Location (UCSC) Chr 7: 97.01 – 97.01 Mb Chr 6: 6.86 – 6.87 Mb PubMed search [3] [4]
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This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family, DLX5, on the long arm of chromosome 7.^[6]