DOCK (protein)
Protein family
From Wikipedia, the free encyclopedia
DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.
Subfamilies
DOCK family proteins are categorised into four subfamilies based on their sequence homology:
- DOCK-A subfamily
- DOCK-B subfamily
- DOCK-C subfamily (also known as Zir subfamily)
- DOCK-D subfamily (also known as Zizimin subfamily)
