DOK1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesDOK1, P62DOK, pp62, docking protein 1
Quick facts Available structures, PDB ...
DOK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOK1, P62DOK, pp62, docking protein 1
External IDsOMIM: 602919; MGI: 893587; HomoloGene: 1057; GeneCards: DOK1; OMA:DOK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291799
NM_010070

RefSeq (protein)

NP_001278728
NP_034200

Location (UCSC)Chr 2: 74.55 – 74.56 MbChr 6: 83.01 – 83.01 Mb
PubMed search[3][4]
Wikidata
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Function

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.[8]

Interactions

DOK1 has been shown to interact with:

References

Further reading

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