DPH5

DPH5
Identifiers
Aliases	DPH5, CGI-30, HSPC143, NPD015, AD-018, diphthamide biosynthesis 5
External IDs	OMIM: 611075; MGI: 1916990; HomoloGene: 6471; GeneCards: DPH5; OMA:DPH5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	101,026,088 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,934,361 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gonad; ; left ovary; ; buccal mucosa cell; ; right adrenal gland; ; ganglionic eminence; ; right adrenal cortex; ; right ovary; ; tibialis anterior muscle; ; ventricular zone;
	Top expressed in
	Paneth cell; ; yolk sac; ; primitive streak; ; endothelial cell of lymphatic vessel; ; motor neuron; ; fossa; ; blastocyst; ; Ileal epithelium; ; condyle; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; diphthine synthase activity;
Cellular component	cytosol; cellular component;
Biological process	methylation; metabolism; peptidyl-diphthamide biosynthetic process from peptidyl-histidine;
	Sources:Amigo / QuickGO
Orthologs
	51611
	69740
	ENSG00000117543
	ENSMUSG00000033554
	Q9H2P9
	Q9CWQ0
	NM_001077394; NM_001077395; NM_015958
	NM_027193
	NP_001070862; NP_001070863; NP_057042
	NP_081469
	Wikidata
View/Edit Human	View/Edit Mouse

Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.^[5]^[6]

AliasesDPH5, CGI-30, HSPC143, NPD015, AD-018, diphthamide biosynthesis 5

External IDsOMIM: 611075; MGI: 1916990; HomoloGene: 6471; GeneCards: DPH5; OMA:DPH5 - orthologs

Chr.Chromosome 1 (human)^[1]

End101,026,088 bp^[1]

Quick facts Identifiers, Aliases ...

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This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis.

The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

DPH5

References

Further reading

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